This book presents a new approach to the protein folding problem it starts with a clear description of what the protein folding problem involves then it suggests non conventional answers to some of the questions posed in particular it emphasizes the importance of hydrophilic interactions and . The protein folding problem is the question of how a proteins amino acid sequence dictates its three dimensional atomic structure the notion of a folding problem first emerged around 1960 with the appearance of the first atomic resolution protein structures. Water solves protein folding problem he points out that protein folding does not occur in isolation but in solution so the amino acid chain is surrounded by water molecules at close range . 11 the computational protein folding problem the protein folding problem is three different problems the folding code the thermodynamic question of how a native structure results from the interatomic forces acting on an amino acid sequence protein structure prediction the com
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