Recent advances in the understanding of the physiological changes which occur in acute liver failure have undoubtedly improved the quality of the supportive care that these patients receive cerebral oedema and sepsis are the commonest causes of death and profound hypotension with multiorgan failure is frequently encountered. Clinical research has concentrated on new drugs such as antiviral agents refinements to well established techniques of liver transplantation and new methods of supporting the failing liver in this review we aim to highlight the most important scientific and clinical advances in hepatology in the past two years. Read the latest articles of clinics and research in hepatology and gastroenterology at sciencedirectcom elseviers leading platform of peer reviewed scholarly literature. Gh could you briefly describe the pathophysiology of alpha 1 antitrypsin deficiency related disease dp alpha 1 antitrypsin alpha 1 at is a protein normally secreted by the liver the main function of which is the inhibition of neutrophil elastase alpha 1 at deficiency occurs in people with a genetic variant in alpha 1 at that results in altered folding of the protein. Recent advances in hepatology recent advances in hepatology marcellin patrick estrabaud emilie 2017 01 01 000000 doi 101111 liv13323 edit orial 1 intr oduction patients earlier moreover global treatment of hcv patients will have a major impact on public health since hcv treatment is associated this editorial of the special issue of liver international emphasizes the with reduced
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