Much medical care in patients with cholestasis is disease specific cholestasis often does not respond to medical therapy of any sort some reports indicate success in children with chronic cholestatic diseases with the use of ursodeoxycholic acid 20 30 mg kg d which acts to increase bile formation and antagonizes the effect of hydrophobic bile acids on biological membranes. Intrahepatic cholestasis of pregnancy icp is a reversible type of hormonally influenced cholestasis it frequently develops in late pregnancy in individuals who are genetically predisposed. Cholestasis learn about the causes symptoms diagnosis treatment from the merck manuals medical consumer version merck manual consumer version the trusted provider of medical information since 1899 people with cholestasis are advised to avoid or stop using any substance that is toxic to the liver such as alcohol and certain drugs. Cholestasis definition cholestasis is a condition caused by rapidly developing acute or long term chronic interruption in the excretion of bile a digestive fluid that helps the body process fat the term is taken from the greek chole bile and stasis standing still description cholestasis is caused by obstruction within the liver intrahepatic . Pathophysiology of neonatal cholestasis this review will focus on the medical management of cholestasis pathophysiology bile secretion is an essential function of the liver by which bile acids are delivered to the intes tine for lipid solubilization and adsorption and metabolic products eg cholesterol bilirubin
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